White matter at various stages of Alzheimer’s disease

  • Vania Karami, Dr Phd student
  • Giulio Nittari, Dr Phd student
  • Francesco Amenta, Professor
Keywords: Alzheimer’s Disease, AD diagnosis, White Matter (WM), Clinical Dementia Rating (CDR), biomarker


Background: To determine whether the brain’s white matter (WM) volume condition provides an accurate insight into the early diagnosis of Alzheimer’s disease (AD).

Objective: Using an automatic system to measure WM from MR images in order to check the potential of WM atrophy to affect the progression of the AD and whether it can be used as a good biomarker.

Methods: We used the Open Access Series of Imaging Studies (OASIS) database. The method consists of a series of morphological operations on the binary images to extract WM volume and calculation of volume and the statistical characteristic of segmented WM.  

Result: There is a significant negative correlation between WM volume and CDR (r=-0.432, p<0.05). The correlation between WM volume and CDR indicates that the severity of the current state of disease is associated with the loss of WM volume. While the AD has mostly been considered as a GM disease, this study approved that AD is characterized by the relevant involvement of the WM, and WM is a cognitive change in the AD.

Conclusion: Our results confirmed that WM volume significantly contributes to the prediction of the AD. A robust and accurate segmentation of WM lesions from MR images can provide importantly
information about the disease status and progression.

Author Biographies

Vania Karami, Dr, Phd student

Master of biomedical engineering, Ph.D. student of telemedicine and telepharmacy, School of Pharmaceutical Sciences and Health Products, University of Camerino, Camerino, Italy

Giulio Nittari, Dr, Phd student

Master of chemical and pharmacy technology, Ph.D. student of telemedicine and telepharmacy, School of Pharmaceutical Sciences and Health Products, University of Camerino, Camerino, Italy

Francesco Amenta, Professor

MD neurology, professor of anatomy School of Pharmaceutical Sciences and Health Products, University of Camerino, Camerino, Italy



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How to Cite
Karami, V., Nittari, G., & Amenta, F. (2019, January 30). White matter at various stages of Alzheimer’s disease. EPH - International Journal of Applied Science (ISSN: 2208-2182), 5(1), 01-09. Retrieved from https://ephjournal.com/index.php/as/article/view/985

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